abstract：:Cell-based studies previously showed that the ATP-binding cassette transporter A1 (ABCA1) transfers cholesterol across mammary epithelial cells (MEC). Data for phospholipid transport are lacking, and it is unclear from which cellular source the transported cholesterol stems, whether this transport activates signaling ...

journal_title：Molecular and cellular endocrinology

authors： Ontsouka CE,Huang X,Aliyev E,Albrecht C

更新日期：2017-01-05 00:00:00

abstract：:Brown adipose tissue (BAT) has been also considered as the main thermogenic organ responsible of maintenance body temperature through heat production. However, a new type of thermogenic fat has been characterized during the last years, the beige or brite fat, that is developed from white adipose tissue (WAT) in respon...

journal_title：Molecular and cellular endocrinology

authors： Contreras C,Nogueiras R,Diéguez C,Medina-Gómez G,López M

更新日期：2016-12-15 00:00:00

abstract：:Diet-induced obesity can lead to detrimental chronic disorders. The severity of this global epidemic has encouraged ongoing research to characterize the mechanisms underlying obesity and its comorbidities. Recent evidence suggests that saturated fatty acids (SFA) in high-fat diets rapidly generate inflammation in the ...

journal_title：Molecular and cellular endocrinology

authors： Tran DQ,Tse EK,Kim MH,Belsham DD

更新日期：2016-12-15 00:00:00

abstract：:Ultraviolet radiation B stimulates both the production of vitamin D3 in the skin and the activation of the skin analog of the hypothalamic-pituitary-adrenal axis (HPA) as well as the central HPA. Since the role of vitamin D3 in the regulation of the HPA is largely unknown, we investigated the impact of 1,25(OH)2D3 and...

journal_title：Molecular and cellular endocrinology

authors： Wierzbicka JM,Żmijewski MA,Piotrowska A,Nedoszytko B,Lange M,Tuckey RC,Slominski AT

更新日期：2016-12-05 00:00:00

abstract：:Spermatogonial stem cells are quiescent, undergo self-renewal or differentiating divisions, thereby forming the cellular basis of spermatogenesis. This cellular development is orchestrated by follicle-stimulating hormone (FSH), through the production of Sertoli cell-derived factors, and by Leydig cell-released androge...

journal_title：Molecular and cellular endocrinology

authors： Crespo D,Assis LHC,Furmanek T,Bogerd J,Schulz RW

更新日期：2016-12-05 00:00:00

abstract：:Previously, we showed that the bio-peptide angiotensin (Ang) II induces interleukin-6 (IL-6) in cultured astrocytes; however, the mechanism(s) involved in this effect were unknown. In the current study, we determined in brainstem and cerebellum astrocytes from the spontaneously hypertensive rat (SHR), the effect of An...

journal_title：Molecular and cellular endocrinology

authors： Gowrisankar YV,Clark MA

更新日期：2016-12-05 00:00:00

abstract：:PANcreatic-DERived factor (PANDER) is a member of a superfamily of FAM3 proteins modulating glycemic levels by metabolic regulation of the liver and pancreas. The precise PANDER-induced hepatic signaling mechanism is still being elucidated and has been very complex due to the pleiotropic nature of this novel hormone. ...

journal_title：Molecular and cellular endocrinology

authors： Athanason MG,Ratliff WA,Chaput D,MarElia CB,Kuehl MN,Stevens SM Jr,Burkhardt BR

更新日期：2016-11-15 00:00:00

abstract：:Recent evidence suggests that the classic gut peptide, Peptide YY (PYY), could play a fundamental role in endocrine pancreatic function. In the present study expression of PYY and its NPY receptors on mouse islets and immortalised rodent and human beta-cells was examined together with the effects of both major circula...

journal_title：Molecular and cellular endocrinology

authors： Khan D,Vasu S,Moffett RC,Irwin N,Flatt PR

更新日期：2016-11-15 00:00:00

abstract：:Thyroid-stimulating hormone (TSH) receptor is expressed in extrathyroidal tissues such as hepatocytes, adipocytes, and skeletal muscle, which suggests a possible novel role of TSH in various metabolic processes in extrathyroidal tissues independent of thyroid hormones. We investigated whether TSH has any effects on gl...

journal_title：Molecular and cellular endocrinology

authors： Moon MK,Kang GH,Kim HH,Han SK,Koo YD,Cho SW,Kim YA,Oh BC,Park do J,Chung SS,Park KS,Park YJ

更新日期：2016-11-15 00:00:00

abstract：:Cardiac fibrosis evolves from the cardiac hypertrophic state. In this respect, estrogen and estrogen receptor beta (ERβ) inhibit the effects of cardiac hypertrophic peptides that also stimulate fibrosis. Here we determine details of the anti-fibrotic functions of ERβ. In acutely isolated rat cardiac fibroblasts. E2 or...

journal_title：Molecular and cellular endocrinology

authors： Pedram A,Razandi M,Narayanan R,Levin ER

更新日期：2016-10-15 00:00:00

abstract：:Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are essential factors in mammary-gland (MG) development and are altered during fasting. However, no studies have investigated the alterations in the expression of GH/IGF-I and its regulatory systems (somatostatin/cortistatin and ghrelin) in MG during fasting...

journal_title：Molecular and cellular endocrinology

authors： Villa-Osaba A,Gahete MD,Cordoba-Chacon J,de Lecea L,Castaño JP,Luque RM

更新日期：2016-10-15 00:00:00

abstract：:In order to study the intracellular cAMP response kinetics of Leydig cells to hormones with LH activity, we used MLTC-1 cells transiently expressing a chimeric cAMP-responsive luciferase so that real-time variations of intracellular cAMP concentration could be followed using oxiluciferin luminescence produced from cat...

journal_title：Molecular and cellular endocrinology

authors： Klett D,Meslin P,Relav L,Nguyen TM,Mariot J,Jégot G,Cahoreau C,Combarnous Y

更新日期：2016-10-15 00:00:00

abstract：:The molecular etiology of follicular thyroid tumors is largely unknown, rendering the diagnostics of these tumors challenging. The somatic alterations present in these tumors apart from RAS gene mutations and PAX8/PPARG translocations are not well described. To evaluate the profile of somatic alteration in follicular ...

journal_title：Molecular and cellular endocrinology

authors： Swierniak M,Pfeifer A,Stokowy T,Rusinek D,Chekan M,Lange D,Krajewska J,Oczko-Wojciechowska M,Czarniecka A,Jarzab M,Jarzab B,Wojtas B

更新日期：2016-09-15 00:00:00

abstract：:Tibolone, a synthetic steroid used for the prevention of osteoporosis and the treatment of climacteric symptoms in post-menopausal women, may exert tissue selective estrogenic actions acting on estrogen receptors (ERs). We previously showed that tibolone protects human T98G astroglial cells against glucose deprivation...

journal_title：Molecular and cellular endocrinology

authors： Avila-Rodriguez M,Garcia-Segura LM,Hidalgo-Lanussa O,Baez E,Gonzalez J,Barreto GE

更新日期：2016-09-15 00:00:00

abstract：:Diabetic cardiomyopathy is characterized by an abnormal oxidative metabolism, but the underlying mechanisms remain to be defined. To uncover potential mechanisms involved in the pathophysiology of diabetic cardiomyopathy, we performed a gene expression profiling study in hearts of diabetic db/db mice. Diabetic hearts ...

journal_title：Molecular and cellular endocrinology

authors： Lasheras J,Vilà M,Zamora M,Riu E,Pardo R,Poncelas M,Cases I,Ruiz-Meana M,Hernández C,Feliu JE,Simó R,García-Dorado D,Villena JA

更新日期：2016-07-15 00:00:00

abstract：:Several common KCNQ1 gene polymorphisms have been associated with the risk of type 2 diabetes (T2DM) and diabetic nephropathy. This effect is explained by the role of the kcnq1 protein as a potassium channel that in the pancreatic beta-cells drives an electrical signal that facilitates glucose-stimulated insulin secre...

journal_title：Molecular and cellular endocrinology

authors： Riobello C,Gómez J,Gil-Peña H,Tranche S,Reguero JR,de la Hera JM,Delgado E,Calvo D,Morís C,Santos F,Coto-Segura P,Iglesias S,Alonso B,Alvarez V,Coto E

更新日期：2016-05-15 00:00:00

abstract：:The food industry is moving towards the use of natural sweeteners such as those produced by Stevia rebaudiana due to the number of health and safety concerns surrounding artificial sweeteners. Despite the fact that these sweeteners are natural; they cannot be assumed safe. Steviol glycosides have a steroidal structure...

journal_title：Molecular and cellular endocrinology

authors： Shannon M,Rehfeld A,Frizzell C,Livingstone C,McGonagle C,Skakkebaek NE,Wielogórska E,Connolly L

更新日期：2016-05-15 00:00:00

abstract：:Gonadotropin-releasing hormone (GnRH) neurons coordinate reproduction. However, whether GnRH neurons directly sense free fatty acids (FFAs) is unknown. We investigated the individual effects of the FFAs docosahexaenoic acid (DHA), palmitate, palmitoleate, and oleate (100 μM each) on Gnrh mRNA expression in the mHypoA-...

journal_title：Molecular and cellular endocrinology

authors： Tran DQ,Ramos EH,Belsham DD

更新日期：2016-05-05 00:00:00

abstract：:Insulin-like growth factor binding protein-1 (IGFBP-1), secreted by fetal liver, is a key regulator of IGF-I bioavailability and fetal growth. IGFBP-1 phosphorylation decreases IGF-I bioavailability and diminishes its growth-promoting effects. Growth-restricted fetuses have decreased levels of circulating essential am...

journal_title：Molecular and cellular endocrinology

authors： Malkani N,Biggar K,Shehab MA,Li SS,Jansson T,Gupta MB

更新日期：2016-04-15 00:00:00

abstract：:Endometriosis, one of the most common benign gynecological diseases, affects millions of women of childbearing age. Endometriosis-associated pain is a major cause of disability and compromised quality of life in women. Neuropathic mechanisms are believed to play an important role. An imbalanced sympathetic and sensory...

journal_title：Molecular and cellular endocrinology

authors： Liang Y,Yao S

更新日期：2016-03-15 00:00:00

abstract：:The underlying mechanism leading to rupture of the membranes at parturition is not fully understood. Lysyl oxidase (LOX) cross-links collagen fibrils thereby increasing the tensile strength of the membranes. Thus, understanding the regulation of LOX expression may be of crucial importance for elucidation of the proces...

journal_title：Molecular and cellular endocrinology

authors： Liu C,Zhu P,Wang W,Li W,Shu Q,Chen ZJ,Myatt L,Sun K

更新日期：2016-03-15 00:00:00

abstract：:Resistance to thyroid hormone can be due to heterozygous, dominant negative (DN) THRA (RTHα) or THRB (RTHβ) mutations, but the underlying mechanisms are incompletely understood. Here, we delineate the spatiotemporal expression of TH receptors (TRs) in zebrafish and generated morphants expressing equivalent amounts of ...

journal_title：Molecular and cellular endocrinology

authors： Marelli F,Carra S,Agostini M,Cotelli F,Peeters R,Chatterjee K,Persani L

更新日期：2016-03-15 00:00:00

abstract：:The classic renin-angiotensin system (RAS) is a complex system in which angiotensin II (Ang II) has been identified as an important endogenous regulator that influences both smooth muscle contraction and cell growth. Although a local RAS is known to exist in the gastrointestinal tract, it is unclear whether Ang II is ...

journal_title：Molecular and cellular endocrinology

authors： Zhang CM,Huang X,Lu HL,Meng XM,Liu DH,Kim YC,Xu WX

更新日期：2016-03-05 00:00:00

abstract：:Mutations in Thyroglobulin (TG) are common genetic causes of congenital hypothyroidism (CH). But the TG mutation spectrum and its frequency in Chinese CH patients have not been investigated. Here we conducted a genetic screening of TG gene in a cohort of 382 Chinese CH patients. We identified 22 rare non-polymorphic v...

journal_title：Molecular and cellular endocrinology

authors： Hu X,Chen R,Fu C,Fan X,Wang J,Qian J,Yi S,Li C,Luo J,Su J,Zhang S,Xie B,Zheng H,Lai Y,Chen Y,Li H,Gu X,Chen S,Shen Y

更新日期：2016-03-05 00:00:00

abstract：:Delphinidin possesses the highest chemopreventive activity among the six components of anthocyanidin that are pigments from fruits and vegetables giving them blue, purple or red colors. Although delphinidin has anti-carcinogenic and apoptotic effects in various cancers, little is known about its functional roles in ov...

journal_title：Molecular and cellular endocrinology

authors： Lim W,Jeong W,Song G

更新日期：2016-02-15 00:00:00

abstract：:The molecular basis of the organogenesis, homeostasis, and tumorigenesis of the adrenal cortex has been the subject of intense study for many decades. Specifically, characterization of tumor predisposition syndromes with adrenocortical manifestations and molecular profiling of sporadic adrenocortical tumors have led t...

journal_title：Molecular and cellular endocrinology

authors： Basham KJ,Hung HA,Lerario AM,Hammer GD

更新日期：2016-02-05 00:00:00

abstract：:Oxytocin (OT) plays an important role in the onset of human labour by stimulating uterine contractions and promoting prostaglandin/inflammatory cytokine synthesis in amnion via oxytocin receptor (OTR) coupling. The OTR-antagonist, Atosiban, is widely used as a tocolytic for the management of acute preterm labour. We f...

journal_title：Molecular and cellular endocrinology

authors： Kim SH,MacIntyre DA,Hanyaloglu AC,Blanks AM,Thornton S,Bennett PR,Terzidou V

更新日期：2016-01-15 00:00:00

abstract：:Adult neurogenesis occurs in neural stem cell (NSC) niches where slow cycling stem cells give rise to faster cycling progenitors. In the adult mouse NSC niche thyroid hormone, T3, and its receptor TRα act as a neurogenic switch promoting progenitor cell cycle completion and neuronal differentiation. Little is known ab...

journal_title：Molecular and cellular endocrinology

authors： Préau L,Le Blay K,Saint Paul E,Morvan-Dubois G,Demeneix BA

更新日期：2016-01-15 00:00:00

abstract：:Iodide Organification defects (IOD) represent 10% of cases of congenital hypothyroidism (CH) being the main genes affected that of TPO (thyroid peroxidase) and DUOX2 (dual oxidasa 2). From a patient with clinical and biochemical criteria suggestive with CH associated with IOD, TPO and DUOX2 genes were analyzed by mean...

journal_title：Molecular and cellular endocrinology

authors： Belforte FS,Citterio CE,Testa G,Olcese MC,Sobrero G,Miras MB,Targovnik HM,Rivolta CM

更新日期：2016-01-05 00:00:00

abstract：:The prediction of invasion or malignant behavior in PAs remains challenging. FSCN1, an actin-bundling protein, is associated with increased risk of mortality and metastasis in various cancer types. The objective of the study was to evaluate the expression of FSCN1 in 312 PAs cases, and to analyze its association with ...

journal_title：Molecular and cellular endocrinology

authors： Liu C,Gao H,Cao L,Gui S,Liu Q,Li C,Li D,Gong L,Zhang Y

更新日期：2016-01-05 00:00:00

abstract：:Granulosa cell (GC) expressed androgen receptors (AR) and intrafollicular androgens are central to fertility. The transactivating domain of the AR contains a polymorphic CAG repeat sequence, which is linked to the transcriptional activity of AR and may influence the GC function. This study aims to evaluate the effects...

journal_title：Molecular and cellular endocrinology

authors： Borgbo T,Macek M Sr,Chrudimska J,Jeppesen JV,Hansen LL,Andersen CY

更新日期：2016-01-05 00:00:00

abstract：:Metabolic syndrome (MetS) is a disease composed of different risk factors such as obesity, type 2 diabetes or dyslipidemia. The prevalence of this syndrome is increasing worldwide in parallel with the rise in obesity. Nonalcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in western co...

journal_title：Molecular and cellular endocrinology

authors： Asrih M,Jornayvaz FR

更新日期：2015-12-15 00:00:00

abstract：:Humans maintain core temperature through a complex neuroendocrine circuitry, coupling environmental thermal and nutritional cues to heat-producing and dissipating mechanisms. Up to 40% of resting energy expenditure contributes to thermal homeostasis maintenance. Recent re-discovery of thermogenic brown adipose tissue ...

journal_title：Molecular and cellular endocrinology

authors： Lee P,Greenfield JR

更新日期：2015-12-15 00:00:00

abstract：:Fibroblast growth factor (FGF)-21 is an endocrine member of the FGF family with healthy effects on glucose and lipid metabolism. FGF21 reduces glycemia and lipidemia in rodent models of obesity and type 2 diabetes. In addition to its effects improving insulin sensitivity, FGF21 causes weight loss by increasing energy ...

journal_title：Molecular and cellular endocrinology

authors： Giralt M,Gavaldà-Navarro A,Villarroya F

更新日期：2015-12-15 00:00:00

abstract：:Although parathyroid hormone (PTH) has long been known to act as a bone anabolic agent when administered intermittently, the exact underlying mechanisms remain largely unknown. Amphiregulin (AREG), a ligand of the epidermal growth factor receptor, has been identified to be a PTH target gene in vitro and in vivo. Here,...

journal_title：Molecular and cellular endocrinology

authors： Jay FF,Vaidya M,Porada SM,Andrukhova O,Schneider MR,Erben RG

更新日期：2015-12-05 00:00:00

abstract：:Estrogen replacement therapy (ERT) is utilized as a major regime for treatment of postmenopausal osteoporosis at present. However, long-term supplement of estrogen may cause uterine hyperplasia and hypertension leading to a high risk of endometrial cancer and breast cancer. Psoralea corylifolia L. has long been used a...

journal_title：Molecular and cellular endocrinology

authors： Weng ZB,Gao QQ,Wang F,Zhao GH,Yin FZ,Cai BC,Chen ZP,Li WD

更新日期：2015-12-05 00:00:00

abstract：:Brown fat has been highlight as a new therapeutic target for treatment of obesity and diabetes. However, molecular mechanism underlying brown adipogenesis are not fully understood. Here, we identified that MAP kinase phosphatase 3 (MKP3) has a novel role as regulator of brown adipocyte differentiation. The expression ...

journal_title：Molecular and cellular endocrinology

authors： Kim WK,Oh KJ,Choi HR,Park A,Han BS,Chi SW,Kim SJ,Bae KH,Lee SC

更新日期：2015-11-15 00:00:00

abstract：:A recent hypothesis suggests that a high glycaemic load diet-associated increase of insulin-like growth factor-1 (IGF-1) and insulin may promote acne by reducing nuclear localization of the forkhead box-O1 (FoxO1) transcription factor via activation of the phosphoinositide-3-kinase (PI3K)/Akt pathway. Using SZ95 seboc...

journal_title：Molecular and cellular endocrinology

authors： Mirdamadi Y,Thielitz A,Wiede A,Goihl A,Papakonstantinou E,Hartig R,Zouboulis CC,Reinhold D,Simeoni L,Bommhardt U,Quist S,Gollnick H

更新日期：2015-11-05 00:00:00

abstract：:In the extracellular space, the gonadotropin-releasing hormone (GnRH) is metabolized by the zinc metalloendopeptidase EC3.4.24.15 (EP24.15) to form the pentapeptide, GnRH-(1-5). GnRH-(1-5) diverges in function and mechanism of action from GnRH in the brain and periphery. GnRH-(1-5) acts on the orphan G protein-coupled...

journal_title：Molecular and cellular endocrinology

authors： Cho-Clark M,Larco DO,Zahn BR,Mani SK,Wu TJ

更新日期：2015-11-05 00:00:00

abstract：:The Nile tilapia, Oreochromis niloticus, is a gonochoristic teleost fish with an XX/XY genetic system and is an excellent model for gonadal sex differentiation. In the present study, we screened novel genes that were expressed predominantly in either XY or XX undifferentiated gonads during the critical period for diff...

journal_title：Molecular and cellular endocrinology

authors： Kaneko H,Ijiri S,Kobayashi T,Izumi H,Kuramochi Y,Wang DS,Mizuno S,Nagahama Y

更新日期：2015-11-05 00:00:00